It starts innocently. One day you find yourself replacing Apple Maps with Google Maps when it becomes available. Or maybe you fall in love with a new email application. You find, after not really using the default calendar app that there are more robust options out there.Source: http://feedproxy.google.com/~r/Techcrunch/~3/zqDj6667B6I/
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Princeton University evacuated its campus Tuesday morning in response to a bomb threat to "multiple unspecified" buildings, the school announced in an emergency bulletin.
All employees were directed to leave university offices at the Princeton, N.J., campus and were told, "Do not return to campus for any reason."
Bomb threat on campus. Pls evacuate campus and offices and go home. Updates to follow. Check email. NOT A TEST.
According to a tweet from the university, those without a vehicle to leave campus are being directed to an evacuation site by Princeton police.
Princeton said just after noon that it does not expect employees to return to work on Tuesday as it investigates the bomb threat.
"The University's Department of Public Safety is investigating the threat with local, state and federal law enforcement agencies," an update on the website said.
The spring semester has already concluded and commencement was held last week. Princeton spokesman Dan Day told WNBC there are some summer programs on campus.
The FBI is not participating at this time in the Princeton investigation, a representative told The Huffington Post, but cautioned "that can change at anytime."
Students who need a place to go are being directed to the Nassau Inn, Princeton Public Library and Princeton Arts Council building downtown.
A university update on Tuesday afternoon announced that authorities are currently inspecting buildings on Princeton's campus using bomb-sniffing dogs, and the search of campus facilities is expected to take several hours.
A bomb threat was also made on Tuesday near the Georgia State Capitol in Atlanta, USA Today reports.
This is a developing story, check back for updates.
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Source: http://www.huffingtonpost.com/2013/06/11/princeton-bomb-threat_n_3421603.html
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Public release date: 10-Jun-2013
Share ] Contact: Dr. Thomas Efferth
efferth@uni-mainz.de
49-613-139-25751
Johannes Gutenberg Universitaet Mainz
African medicinal plants contain chemicals that may be able to stop the spread of cancer cells. This is the conclusion of researchers following laboratory experiments conducted at Johannes Gutenberg University Mainz (JGU). The plant materials will now undergo further analysis in order to evaluate their therapeutic potential. "The active substances present in African medicinal plants may be capable of killing off tumor cells that are resistant to more than one drug. They thus represent an excellent starting point for the development of new therapeutic treatments for cancers that do not respond to conventional chemotherapy regimens," explained Professor Thomas Efferth of the Institute of Pharmaceutical Sciences and Biochemistry Therapeutic Life Sciences at Mainz University. For the past four years, Efferth and biochemist Dr. Victor Keute of the University of Dschang in Cameroon have been studying the active substances in African plants such as the giant globe thistle, wild pepper, speargrass, and Ethiopian pepper.
Multi-drug resistance is one of the most feared problems in cancer therapy because in such cases most of the standard chemical cancer drugs used in therapy fail and the patient's chance of survival is thus dramatically reduced. The problem cannot usually be resolved by simply increasing the dosage as this also results in the exacerbation of undesirable side effects. "We are now looking for substances that can both break down tumor resistance and not produce side effects," continued Efferth, who also works with medicinal plants used in traditional Chinese medicine.
Many plants contain toxic substances that they use to protect themselves against predators and microbial diseases. Over the course of millions of years during which life has evolved on earth plants have managed to appropriate certain molecules to help them to offset their main disadvantage in the face of their enemies, i.e., their immobility and lack of an immune system. The challenge for the pharmacologists is now to determine which plant substances are medicinal and which are simply poisonous and dangerous.
During the joint project with Mainz, the Cameroonian scientist Victor Kuete has examined more than 100 spices and plants from his homeland for their cytotoxic effects on cancer cells. Awarded a Humboldt Research Fellowship, he can now continue and extend his investigations as a member of Thomas Efferth's work group in Mainz. "We have already found an entire series of benzophenones and other phytochemicals that are able to elude resistance mechanisms and thus offer many new opportunities for continued research," said Efferth.
The researchers are focusing on three different resistance mechanisms. Transporter-mediated resistance prevents drugs taking effect because a substance called P-glycoprotein promotes their efflux from cancer cells. In the case of tumor-suppressor-gene-mediated resistance, a mutation in protein p53 means that the cancer cells do not die but are resistant and become increasingly aggressive. Lastly, in oncogene-mediated resistance, the epidermal growth factor receptor (EGFR) sends signals into the interior of cells causing tumors to grow faster. The researchers in Mainz have cellular models of all three resistance mechanisms that will enable them to appropriately test the effectiveness of the substances obtained from plants.
In their latest of a total of eight publications produced to date, the research team reports that four naturally occurring benzophenones can prevent the proliferation of the tested cancer cell lines, including multi-drug resistant strains. "The benzophenones investigated are potentially cytotoxic substances that need to be more extensively investigated with the aim of developing new cancer drugs that are effective against susceptible and resistant cancers", claims the article recently published in the scientific journal Phytomedicine.
###
Images:
http://www.uni-mainz.de/bilder_presse/09_pharma_heilpflanzen_piper_capensis.jpg
Wild pepper seeds
photo: Victor Kuete, Institute of Pharmaceutical Sciences and Biochemistry Therapeutic Life Sciences
http://www.uni-mainz.de/bilder_presse/09_pharma_heilpflanzen_echinops_giganteus.jpg
Sections of the root of the giant globe thistle
photo: Victor Kuete, Institute of Pharmaceutical Sciences and Biochemistry Therapeutic Life Sciences
Publications:
Victor Kuete et al.
Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2_,5,6_-Tetrahydroxybenzophenone,
guttiferone E, isogarcinol and isoxanthochymol
Phytomedicine, April 2013
DOI: 10.1016/j.phymed.2013.02.003
Victor Kuete et al.
Anticancer Activities of Six Selected Natural Compounds of Some Cameroonian Medicinal Plants
PLoS ONE, August 2011
DOI:10.1371/journal.pone.0021762
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 10-Jun-2013 Share ] Contact: Dr. Thomas Efferth
efferth@uni-mainz.de
49-613-139-25751
Johannes Gutenberg Universitaet Mainz
African medicinal plants contain chemicals that may be able to stop the spread of cancer cells. This is the conclusion of researchers following laboratory experiments conducted at Johannes Gutenberg University Mainz (JGU). The plant materials will now undergo further analysis in order to evaluate their therapeutic potential. "The active substances present in African medicinal plants may be capable of killing off tumor cells that are resistant to more than one drug. They thus represent an excellent starting point for the development of new therapeutic treatments for cancers that do not respond to conventional chemotherapy regimens," explained Professor Thomas Efferth of the Institute of Pharmaceutical Sciences and Biochemistry Therapeutic Life Sciences at Mainz University. For the past four years, Efferth and biochemist Dr. Victor Keute of the University of Dschang in Cameroon have been studying the active substances in African plants such as the giant globe thistle, wild pepper, speargrass, and Ethiopian pepper.
Multi-drug resistance is one of the most feared problems in cancer therapy because in such cases most of the standard chemical cancer drugs used in therapy fail and the patient's chance of survival is thus dramatically reduced. The problem cannot usually be resolved by simply increasing the dosage as this also results in the exacerbation of undesirable side effects. "We are now looking for substances that can both break down tumor resistance and not produce side effects," continued Efferth, who also works with medicinal plants used in traditional Chinese medicine.
Many plants contain toxic substances that they use to protect themselves against predators and microbial diseases. Over the course of millions of years during which life has evolved on earth plants have managed to appropriate certain molecules to help them to offset their main disadvantage in the face of their enemies, i.e., their immobility and lack of an immune system. The challenge for the pharmacologists is now to determine which plant substances are medicinal and which are simply poisonous and dangerous.
During the joint project with Mainz, the Cameroonian scientist Victor Kuete has examined more than 100 spices and plants from his homeland for their cytotoxic effects on cancer cells. Awarded a Humboldt Research Fellowship, he can now continue and extend his investigations as a member of Thomas Efferth's work group in Mainz. "We have already found an entire series of benzophenones and other phytochemicals that are able to elude resistance mechanisms and thus offer many new opportunities for continued research," said Efferth.
The researchers are focusing on three different resistance mechanisms. Transporter-mediated resistance prevents drugs taking effect because a substance called P-glycoprotein promotes their efflux from cancer cells. In the case of tumor-suppressor-gene-mediated resistance, a mutation in protein p53 means that the cancer cells do not die but are resistant and become increasingly aggressive. Lastly, in oncogene-mediated resistance, the epidermal growth factor receptor (EGFR) sends signals into the interior of cells causing tumors to grow faster. The researchers in Mainz have cellular models of all three resistance mechanisms that will enable them to appropriately test the effectiveness of the substances obtained from plants.
In their latest of a total of eight publications produced to date, the research team reports that four naturally occurring benzophenones can prevent the proliferation of the tested cancer cell lines, including multi-drug resistant strains. "The benzophenones investigated are potentially cytotoxic substances that need to be more extensively investigated with the aim of developing new cancer drugs that are effective against susceptible and resistant cancers", claims the article recently published in the scientific journal Phytomedicine.
###
Images:
http://www.uni-mainz.de/bilder_presse/09_pharma_heilpflanzen_piper_capensis.jpg
Wild pepper seeds
photo: Victor Kuete, Institute of Pharmaceutical Sciences and Biochemistry Therapeutic Life Sciences
http://www.uni-mainz.de/bilder_presse/09_pharma_heilpflanzen_echinops_giganteus.jpg
Sections of the root of the giant globe thistle
photo: Victor Kuete, Institute of Pharmaceutical Sciences and Biochemistry Therapeutic Life Sciences
Publications:
Victor Kuete et al.
Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2_,5,6_-Tetrahydroxybenzophenone,
guttiferone E, isogarcinol and isoxanthochymol
Phytomedicine, April 2013
DOI: 10.1016/j.phymed.2013.02.003
Victor Kuete et al.
Anticancer Activities of Six Selected Natural Compounds of Some Cameroonian Medicinal Plants
PLoS ONE, August 2011
DOI:10.1371/journal.pone.0021762
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-06/jgum-sfa061013.php
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This week, CrunchBase released the?May Excel Export Sheet, which includes charts and graphs that illustrate recent U.S. investments, acquisitions, IPOs and more. Though the charts and graphs focus on May's data, the spreadsheet includes historical data on all U.S.-based companies that have received funding.Source: http://feedproxy.google.com/~r/Techcrunch/~3/-cWQql8M8kQ/
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June 10, 2013 ? Lone people standing in a ballroom don't tend to move a lot. It's only when they find a suitable dance partner that rapid motion sets in. Atoms on iron-oxide surfaces behave in a similar way: Only with the right molecular partner do they dance across the surface. Scientists at the Vienna University of Technology have now filmed the atoms, proving that carbon monoxide is the partner responsible for the quick motion. Their movies show that the motion leads directly to clustering -- an effect that can do great harm in catalysts.
The findings have now been published in the journal Nature Materials.
Clusters -- What a Waste of Atoms!
"Metals such as gold or palladium are often used as catalysts to speed up certain chemical reactions," says Professor Ulrike Diebold (Institute of Applied Physics, Vienna University of Technology). When the atoms ball together, most of them do not get into contact with the surrounding gas any more and the catalytic effect diminishes drastically. For this reason, Ulrike Diebold's team investigates how clusters form from single atoms on a surface, and search for ways to inhibit the process.
Theories about this effect have been discussed for years, but the researchers at the Vienna University of Technology have now directly observed the clustering of the atoms. "We are using palladium atoms on an extremely clean iron-oxide surfaces in an ultra high vacuum chamber. For several hours, we take pictures of the surface with a scanning tunneling microscope," says Gareth Parkinson (Vienna University of Technology). These pictures were then made into a movie, in which the paths of the individual atoms could be tracked.
The Skyhook Effect
Using this technique, the research team discovered that the rapid atomic dance on the surface is initiated by carbon monoxide molecules, which bind to individual palladium atoms. As soon as this happens, the palladium is hardly connected to the ground and can move around almost freely, as if it had been lifted out by the carbon monoxide. "This is known as the skyhook effect," says Zbynek Novotny (Vienna University of Technology).The carbon monoxide and palladium move happily together across the surface, until they collide with other 'dancing couples'. Then, they stick together creating a small cluster that continues to grow.
Hydroxyl Against Clustering?
With the new possibility of watching clustering in real-time under the microscope, the mechanisms can now be studied in detail: "We discovered that OH groups on the surface can suppress the clustering effect," says Gareth Parkinson. If the carbon monoxide-palladium couples do not encounter each other, but instead find an OH group, they get trapped there and cannot form a cluster. A hydroxyl coating of the surface could therefore lead to a significant improvement of the stability of catalysts.
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It’s fair to say that the “ambient location” craze has passed. Several of the mobile apps intent on connecting people with friends and other recommended users nearby are still struggling to find mainstream adoption. Some, like Glancee and Glassmap have sold. Others, like Kismet, have moved into new product categories. And today, the business-focused networking app Intro, is pivoting. Gone are the “ambient location” features which once alerted you to nearby users based on things like geotagged tweets or check-ins. With the new version, the company has shifted the focus solely to making one-to-one introductions between members of LinkedIn or Meetup groups. Explains co-founder?Anthony Erwin, the decision to make this switch came from observations of user behavior. The best and most powerful introductions the app enabled were those where the members were each in the same group already. 90 percent of the time when an intro was created and members would connect, they cited being in the same group as the reason, he says. “I think what’s happened in this space, is because it’s dealing with connecting strangers – people are kind of wary of that,” says Erwin. “If you’re going to create connections that work, they’re going to have to be very familiar; almost not like strangers, in a way.” Users told him that when they were shown other group members, those people didn’t feel like random strangers. Intro has always been more sensitive to the potentially creepy nature of ambient location apps, having previously introduced features that would allow users to switch of networking with those not outside of a set of preferred groups, for instance. The revamped version of the app is something of an extension of that earlier concept more than it is a hard pivot to an entirely new vertical. In the updated application, available now on iOS and for Android in a few weeks time (currently the Android app is the older version of Intro), you’ll still be shown other group members who are nearby, but now the app take a wider view of your location. It begins by offering you connections across your city, as opposed to at your exact location. You can then quickly swipe through the suggestions to connect or reject the proposed connections. However, when there is an event or other congregation of members in the same location, the app’s algorithm will immediately adjust to sort its recommendations by degreesSource: http://feedproxy.google.com/~r/Techcrunch/~3/mFt0KUibQtg/
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